šŸ’§ FDA rejects MDMA-assisted therapy for PTSD

PLUS, ayahuasca users shamed by AA

Happy Drop In day! We hope you had a blissful weekend. Weā€™re integrating into this new week by reflecting on our beloved MDMA ā€” and if youā€™re reading this email, youā€™ve also likely spent some energy since last Friday thinking about it, too. 

If you have no idea what Iā€™m talking about, the FDA made a breathtaking decision to deny MDMA-assisted therapy as a viable treatment for PTSD. Itā€™s a lot to process. All we know is that Sasha Shulgin is rolling over in his grave right now. 

Journalist Mattha Busby broke the news for DoubleBlind. You can read that story below! Keep scrolling and youā€™ll find pieces about the development of a new ketamine analog thatā€¦wonā€™t be scheduled under the Controlled Substances Act (!?!), people in AA getting shamed for using ayahuasca, and a guide on how to prepare for your first mushroom trip!

Itā€™s hot AF out there! Eat fruit, stay hydrated, and dose safely. 

šŸ«¶šŸ«¶šŸ«¶,

Mary CarreĆ³n
Senior Editor

The FDA Officially Denies MDMA-Assisted Therapy as PTSD Treatment

The FDA denies Lykos Therapeutics' push to legalize MDMA-assisted therapy, citing limitations that prevent the agency from deeming the drug safe.

The movement to legalize psychedelic medicine has been dealt a huge setback. Federal regulators in the US on Friday declined to approve an MDMA-assisted therapy protocol for the treatment of PTSD, citing issues with the proposed therapy program and a lack of convincing data.

Officials from the Food and Drugs Administration (FDA) said the application for a new drug made by Lykos Therapeutics, the pharmaceutical organization that was formerly the Multidisciplinary Association for Psychedelic Studies Public Benefit Company (MAPS PBC), had ā€œsignificant limitationsā€ that ā€œprevent the agency from concluding that the drug is safe and effective for the proposed indication.ā€

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Our Latest

Mira Pharmaceuticals announced positive preclinical results for Ketamir-2, an oral ketamine analog that penetrates the blood-brain barrier better than traditional ketamine and is less likely to cause side effects. Following this, the DEA stated Ketamir-2 is not a controlled substance, leading to a significant surge in Mira's stock.

Recovering alcoholics whoā€™ve opened up about using ayahuasca are facing significant backlash from the Alcoholics Anonymous (AA) community, the New York Post reports. The controversy stems from the core AA principle of total abstinence from all mind-altering substances, including psychedelics and cannabis. Many members believe ayahuasca violates this core principle, even when used for therapeutic purposes.

Most music aficionados are aware of the most well-known bands inspired by psychedelics: The Beatles, The Grateful Dead, etc. But a number of modern pop, hip hop, and electronic artists have similarly drawn upon psychedelic experiences in their creative pursuits. Here are a few artists and bands who have openly spoken about their psychedelic influences.

& More Must-Reads

Trip Tales

ā

Everything was black. My consciousness was aware and panicky, but there was nothing physical about me. After what seemed like 10 minutes, colorful geometric patterns and swirls appeared. I thought omg I'm trapped, I began to panic, but quickly I was able to remember that I need to calm down and breathe. The colors were vibrant and changing. Only my consciousness was present. I began to relax and I could feel my breath calming. I was coming back.

ā€” Chad D., TX, USA

Have you had a profound experience with psychedelics before? Share your story with us for a chance to be featured in The Drop In. Submit your entry here.

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Learn with Us

šŸ„ Anatomical differences are key to identifying mushrooms. Hereā€™s our guide covering basic mushie anatomy and common examples, highlighting how forms vary between species.

āœļø Everyone has the capacity to be an artist ā€” especially if youā€™re creating trippy art. Here are some tips on making your own psychedelic artwork.

šŸ‘ļø Getting ready to embark on your first shroom trip? Not sure where to start? Hereā€™s everything you need to know to get started.

šŸŒ¼ Damiana is a popular smokable herb and supplement. So, is it really an aphrodisiac? Letā€™s explore.

DoubleBlind Supports

DONATE: Historias y Memorias Mazatecas, supported by the Fungi Foundation, preserves Mazatec cultural heritage with an extensive archive of records, textiles, artifacts, and rare media. Recognizing their influence on the psychedelic community, it's time to show our support and give back. Click here to learn more and donate today.

OPPORTUNITY: Amazon Frontlines, a 501(c)(3) nonprofit based in the Ecuadorian Amazon dedicated to protecting the Western Amazon Basin, indigenous cultures, and our global climate, is hiring an Executive Coordinator. This is an exciting opportunity to be at the center of a dynamic and passionate multicultural network of people who are deeply committed to the fight to protect the Amazon, indigenous cultures and our global climate. Learn more and apply here.

At DoubleBlind, we believe in reciprocityā€”the idea that everything in the world is interconnected and that we have a responsibility to uplift a psychedelic ecosystem that centers equity, inclusivity, and healing for all. Through our work, we hope to help our community participate in this effort with us.

From the Magazine

Indigenous languages are disappearing at an alarming rateā€”and so is the knowledge embedded within them.

Earthā€™s human inhabitants speak about 6,700 different languages. Nearly 60 percent of those languages are spoken by indigenous people, who comprise only six percent of the global population. Often highly localized, with roots in tradition and homeland, indigenous languages mirror the diversity of native cultures worldwide. 

Yet under the pressures of globalizationā€”including poverty, migration, and cultural assimilationā€”indigenous languages are disappearing at alarming rates. The United Nations estimates that up to 95 percent of the worldā€™s languages will be extinct or seriously endangered by the end of this century.

Latest Youtube Video

Here Are the Largest Electronic Music Festivals on Planet Earth

In ancient times, festivals offered an opportunity to celebrate religious holidays and practice sacred rituals. Todayā€™s electronic music festivals arenā€™t quite so traditional but have the same communal power. 

Weā€™re covering the largest festivals on earth over on our YouTube. Watch the video now.

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